Documentation on Amazon Herbs
June 1999

Formula: Shipibo Treasure Tea

Statement: Potent recipe to provide you with balanced vitality and maximum
clarity.

Documentation:

1 Screening for Antifungal Activity of Panamanian Plants by R.A. Halison et al. Int J
Pharmacog 31, 1993 No. 1, 68-76. Jatoba (Hymenaea courbaril) and 152 other
crude plant extracts were tested for antifungal activity against Candida albicans
and Cladosporium cucmerinum. Activity was assessed in a semiquantitative
fashion by bioautography on TLC plates. When tested at 100ug, Jatoba
leaves-stem and also bark chloroform extract were effective against both fungi and
Jatoba leaves-stem methanol was effective against Cladosporium cucmerium.

2 Medicinal Plants of Surinam IV by R. Verporrte and P.P. Dihal. Jour of Ethnopharm
21, 1987, 315-18. "The bark of Jatoba is active against Staphylococcus aureus
and Bacillus subtilis."

3 U.S. Patent 5302, 611. April 12, 1994. Oxindole Alkaloids Having Properties
Stimulating the Immunological System and Preparation Containing Same. Keplinger
et al. "Tetra and pentacyclic oxindole alkaloids, in particular the alloisopteropodine,
isomer A, a pentacyclic oxindole alkaloid, are suitable for the unspecific stimulation
of the immunologic system, which has been proved by a substantial percentage
phagocytosis increase in the granulocytic test according to BRANDT, a substantial
percentage increase of the CL-response in the chemiluminescence test and a high
increase of the phagocytosis activity of tissue macrophages of the
reticuloendothelial system in the carbon clearance test according to BIOZZI.
These alkaloids may be isolated from extracts of the roots of the Uncaria
tomentosa whose fresh best has a yellow brown or dark red color, from which the
tanning substances have largely been removed. The isopteropodine-containing
roots showed values between 30 and 40% activity increase on the average. The
examination of the raw alkaloid mixture in the water-soluble hydrochloride form
showed an average phagocytosis increase of 20%."

4 New Quinovic Acid Glycosides from Uncaria tomentosa by Riccardo Cerri. J Nat
Products, Vol. 51, No. 2, 257-261, Mar-Apr 1988. An aqueous and ethanolic
extract of Uncaria tomentosa showed cytostatic activity. A number of alkaloids
show a pronounced enhancement of phagocytosis.

5 Plant Metabolites. Structure and In Vitro Antiviral Activity of Quinovic Acid
Glycosides from Uncaria tomentosa and Guettarda platypoda. J Nat Products, Vol.
52, No. 4, 1989, 679-685. A series of antiviral tests were performed on the
quinovic acid glycosides in Uncaria tomentosa. The quinovic acid compounds
inhibited vesicular stomatitis virus.

6 Die Alkaloide von Uncaria tomentosa und ihre Phagozytosesteigernde Wirkung by
H. Wagner, B. Kreutzkamp and K. Jurcie, Planta Medica 1985, 419-423. "Of the six
oxindole alkaloids isolated and identified from the roots of Uncaria tomentosa, all
except mitraphyllin and rynchophyllin showed a pronounced enhancement of
phagocytosis. This was determined in two in vitro tests and the in vivo carbon
clearance test. The active alkaloids include isopteropodin, pteropodin, mitraphyllin,
isomitraphyllin, rynchophyllin and isorynchophyllin."

7 Mutagenic and Antimutagenic Activities of Uncaria tomentosa and its Extracts. J
Ethnopharm, Vol. 38, 1993, 63-77. Uncaria tomentosa plant extracts show a
protective antimutagenic effect in vitro against photomutagenesis induced by
8-methoxypsoralen (8-MOP) plus UVA in S. typhirium TA 102. A decoction of U.
tomentosa ingested daily for 15 days by a smoker decreased the mutagenicity
induced in S. typhimurium TA 98 and TA100 by the subject's urine.

8 A Differential Sensitivity of Oxindole Alkaloids to Normal and Leukemic Cell
Lines. Planta Medica, Vol. 59, 1993, A583. "All tested oxindole alkaloids
dose-dependently inhibited the growth of HL60 and U-937 cells. The most
pronounced effect was found for uncarine F with IC50 values (concentration
required to inhibit 50% of the leukemic cells) of 21.7 (HL 60) and 29.0 (U 937)
umol/1."

9 The Healing Power of Herbs, 2nd edition. By Michael Murray, 1995, 220-227.
Pau d'Arco contains anthroquinones and naphthoquinones. The naphthoquinones
are highly effective against Candida albicans and Tricophyton mentagrophytes.

10 A Lapachol Derivative Active Against Mouse Lymphocytic Leukemia P388 by
M. da Consolamo et al. J Med Chem 18, 11, Nov 1975, 1159-61. "Lapachol and its
derivatives were tested against rat tumor Walker 256 carcinosarcoma and found to
be active. It was also effective against mouse lymphocytic leukemia P388."

11 Inhibition of Potentially Lethal DNA Damage Repair in Human Tumor Cells by
Beta-laprachone, an Activator of Topoisomerase I by D.A. Boothman, D.K. Trask
and A.B. Pardee. Cancer Research Vol. 49, No. 3, Feb 1, 1989, 605-12.
"Beta-lapachone, found in Pau d'Arco, inhibited the fast component of potentially
lethal damage repair carried out by HEP-2 cells when present during or immediately
after x-irradiation. It does not further enhance the lethal effects of x-rays following
prolonged drug exposures. The mechanism of action is through activation of
topoisomerase I."

12 Production of Anti-Tumor-Promoting Furanonaphthoquinones in Tabebuia
avellandae Cell Cultures by S. Ueda et al. Phytochemistry Vol. 36, No. 2, 1994,
323-325. Tabebuia avellanedae (Tabebuia impetiginosa) quinones showed
significant dose-dependent inhibitory effects in in vitro assays utilizing the
activation of Epstein-Barr virus expression in EBV genome-carrying human
lymphoblastoid cells to detect tumor promoters and anti-tumor promoters. These
quinones have demonstrated potent cytotoxicity to human solid tumors in vitro.
(A-549, MCF-7, HT-29)

13 Immunological Investigations of Naphthaquinone-containing Plant Extracts,
Isolated Quinones and other Cytostatic Compounds in Cellular Immunosystems by
H. Wagner, B. Kreher and K. Jurcie. Planta Med 1986 (6), 550-551, P99. "Pau
d'Arco and other herb extracts were tested to see whether their well-known
cytotoxic effects of the naphthaquinones were caused by a direct inhibition of the
cell metabolism or by immuno-induced cytotoxicity. Most extracts and isolated
compounds exerted in high concentrations (1 -0.01 mg/mL) a cytotoxic or
immunosuppressive effect whereas the same preparations in very low concentration
showed in nearly all cases immunostimulating properties. It was concluded that the
induction of cellular and humoral immune factors was responsible for the action."

14 The Honest Herbal by Varro Tyler, 1992. Pg. 239-241. "Lapachol does
possess some anticancer properties. In 1968 it was shown to have significant
activity against Walker 256 carcinosarcoma, particularly when administered orally
to animals on which this tumor had been implanted. In later studies, lapachol was
found to be active against other kinds of animal cancers, including Yoshida sarcoma
and Murphy-Sturm lymphosarcoma."

15 A Lapachol Derivative Active Against Mouse Lymphocytic Leukemia P388 by
M. da Consolamo et al. J Med Chem 18, 11, Nov. 1975, 1159-61. "Lapachol and
its derivatives were tested against rat tumor Walker 256 carcinosarcoma and found
to be active. It was also effective against mouse lymphocytic leukemia P388."

16 Herbal tonic Therapies by Daniel Mowrey. Keats Publishing, Inc., New Canaan,
Connecticut, 1993. Pg. 70-89. "In vivo trials show definite inhibition of free
radicals and the inflammatory leukotrienes by lapacho constituents. One of the
strongest actions of lapacho is against viruses. Antiviral effects are seen against
herpesvirus hominis types I and II, polio virus, vesicular stomatitis virus, avian
mycloblastosis virus, murine leukemia virus, Friend virus, and Rous sarcoma virus.
One factor, beta-lapachone, inhibits reverse transcriptase enzyme. Lapacho was
found to be effective against both Schistosoma mansoni and Trypanosoma cruzi.
Lapacho is often singled out as the premier treatment for Candida or yeast
infections. Toe and fingernail fungal infections are relieved by soaking the
appendages in lapacho tea of and on for a couple of weeks."

17 Comparative Hepatoprotective Activity of Three Phyllanthus Species, P.
urinaria, P. niruri and P. simplex, on Carbon Tetrachloride Induced Liver Injury in
the Rat by a A. Prakash, K.S. Satyan, S.P. Wahi, and R.P. Singh. Phototherapy
Research Vol. 9, 594-596, 1995. "Pretreatment of animals with an alcoholic
extract of P. niruri showed it had significant hepatoprotective activity at doses of
40mg/kg/day (p less than 0.05) and 400 mg/kg/day (p less than 0.01). Further, at
the different doses administered, the extracts showed dose-dependent
hepatoprotective activity."

18 In Vitro Studies on the Effect of Certain Natural Products Against Hepatitis B
virus by Raj Mehrotra et al. Indian J Med Res 92, April 1990, 133-138.
"Anti-HBs-like activity was observed in picroliv, picroside I, kutkoside, P. niruri
extract and catalpol. Silymarin and andrographolide had little or no effect. The
anti-HBs like activity of test compounds/extract was not affected by the presence
of other HBV markers in serum samples and it did not interfere with HBsAg Elisa
system used in the study." P. niruri affected 68% of the 27 serum samples tested.
The effect of P. niruri against HBsAg was high (83%) in AVH and in serum samples
from cirrhosis patients, as compared to HBsAg carriers (38%).

19 Protection Afforded by Aqueous Extracts of Phyllanthus Species Against
Cytotoxicity Induced by Lead and Aluminum Salts by H. Dhir, A. Roy, A. Sharma
and G. Talukder. Phytotherapy Research, Vol. 4, No. 5, 1990. "Oral administration
of aqueous extracts of P. niruri leaves to laboratory bred albino mice for a week
significantly reduced the cytotoxic action of lead nitrate and aluminum sulphate.
The frequency of chromosomal breakages, gaps and rearrangements induced by
three concentrations of these salts was decreased when compared to the control
animals which had received the salts alone."

20 Antihepatotoxic Principles of Phyllantus niruri Herbs by K. Venkata
Syamasunder et al, Jour of Ethnophara 14, 1985, 41-44. "Significant inhibitory
actions were observed with phyllanthin and hypophyllanthin in preventing
CC1-4-produced cell lesions."

21 In Vitro Inactivation of HBsAg by Eclipta alba Hassk and Phyllanthus niruri.
Indian J Med Res 76 (Suppl) Dec 1982, 124-30. Researchers did an in vitro test to
evaluate the in vitro immuno-inactivating ability of plants on hepatitis B surface
antigen. When P. niruri roots and shoots were dried and powdered, the researchers
"revealed a definite immunoinactive property of the plant against the surface
antigen of hepatitis B virus. Further analysis by TLC indicated a red pigment
uniformly present in all the parts of these plants to be the seat of such action."

22 Herbs of Genus Phyllanthus in Treatment of Chronic Hepatitis B: Observations
with 3 Preparations from Different Geographic Sites. J Lab Clin Med 1995, 126:
350-352 "88 Patients with chronic hepatitis B were randomly assigned to get one
of three herbs for three months. 0.3 gm three times a day for the first month; 0.6 gm
three times a day for the second month; 0.9 gm three times a day for the third
month. There were no obvious ill effects. The most striking and promising finding -
substantial incidence of clearance of hepatitis B e-ag from serum as well as a
substantial incidence of appearance of antibody to that antigen."

23 Hypoglycemic Action of Stevia Rebaudiana Bertoni by C.A. Oviedo, C. Ronciani,
R. Moreo, and L.L. Maas. Excerpta Medica, Vol. 209, 92, 1970. These researchers
reported anti-hyperglycemic actions of Stevia in 1970 and beneficial effects in the
treatment of diabetes mellitus. Twenty-five healthy adults were given the dried
aqueous extract orally. An average fall in blood glucose levels of 35.2% was noted
between 6 and 8 hours later.

24 Efeito Hipoglicemiante De Stevia Rebaudiana Bertoni by M. Alvares, R.B.
Bazzone, G.L. Godoy, R. Cury, L.M. Botion. 1st Brazilian Seminar on Stevia
rebaudiana, 1981. Reprint of handout. In 1981 at the 1st Brazilian Seminar on
Stevia rebaudiana, researchers presented findings on the hypoglycemic action of
this herb. Fifteen human participants aged 19-25 years old took the equivalent of 1
gm stevioside per day, divided into 4 applications of 250 mg each, every 6 hours.
The results showed an accentuated hypoglycemic response in the subjects studied.